S-W220

The all-new W221 was introduced in the autumn of 2005 at the Frankfurt International Motor Show, with export to other markets beginning in 2006. The W221 S-Class made its North American premiere at the 2006 North American International Auto Show in January. The latest S-Class is slightly larger in all dimensions than its predecessor, and it features three newly developed engines with up to 26% power increase. The interior is completely new, all materials have been upgraded and make for a more luxurious ride, and the center console transmission gear lever has been replaced with a column-mounted shifter. New technological features on the W221 include an infrared Night View Assist feature and the latest Mercedes-Benz pre-collision system. The W221 features sharper exterior styling (most notably wide fender arcs) and technological improvements. The W221 is the second consecutive generation of the S-Class to be solely produced in a sedan body style.

Models sold in North America are the S450 (2008-, SWB and Canada only), S400 Hybrid (2010- ), S550, S600, S63 AMG and S65 AMG; other models to be sold outside North America include the S280, S350, S300, S420 CDI and S320 CDI. The first W221 model released in North America and Japan was the S550 (called S500 outside North America and Japan), with the S600 arriving in the following spring.^[10][11] Mercedes Benz Mexico also produces a police spec model of the S-600, the S-600P. The S-600P is similar to the standard S-600 but is equipped with the dual turbo charged V-12 engine of the S65 AMG and includes police lights, siren, run-flat tires, a gun mount, a Lanix computer station integrated with the host police network, optional prisoner cage and restraint seats, and level B6/B7 armoring. The S-600P is only built in Mexico and only comes in long-wheelbase version. The Mexican government uses S-600P's mainly for transporting important figures, but several police departments in wealthier cities in the country use them as patrol vehicles, as does the Mexican Federal Police in limited numbers. A small number of S-600P were purchased by the police department of Guangzhou, China for protection of key government figures.