E-W211

Launched in 2002, the W211 E-Class was another evolution of the previous model and was considered by the motoring media as an even more competitive offering to the long term rival BMW 5-Series (which previously was the preferred choice of the motoring media). Before North American sales began, the car was shown in the 2002 movie Men in Black II.

The W211-based W219 CLS-Class 4-door coupé was introduced as a niche model in 2005, primarily to attract a younger demographic.

The W211 E-Class was face lifted in 2007 to address quality and technical issues raised by earlier models, Sensotronic was dropped, while Pre-Safe (w/o brake support) was made standard. The largest factory built engine in the E-class range is the E500 (badged E550 in the U.S.) which had its engine size increased from 5 litres to 5.5 litres in 2006 along with the facelift. There is also an AMG model badged E63 AMG and other tuning house installations.

Mercedes-Benz introduced their BlueTec Diesel system to the E-Class at the 2006 North American International Auto Show as the E320 CDI BlueTec. BlueTec is a two-phase system for cleaning diesel emissions. The first phase makes the E320 CDI legal in 45 of the 50 United States (plus the District of Columbia). The second phase uses urea for further reductions to meet the more stringent standards of California, Maine, Massachusetts, New York, and Vermont. Sales of E320 CDI BlueTec began in autumn 2006 as a 2007 model, but 50-state legal models with urea injection will not be introduced until the 2009 model year.